Understanding Myasthenia Gravis: A Guide for Patients in Oregon
Myasthenia gravis, often called MG, is a chronic neuromuscular condition that causes muscle weakness and fatigue that worsens with activity and improves with rest. At Vital Care of Portland, we provide infusion therapy for patients with generalized MG, including newer FcRn inhibitor treatments like Vyvgart (efgartigimod alfa). If you or someone you love has been diagnosed with MG, here is what you should know about the condition and how infusion therapy fits into treatment.
What Is Myasthenia Gravis?
Myasthenia gravis is an autoimmune condition in which the immune system produces antibodies that interfere with communication between nerves and muscles. The result is weakness that can affect the eyes, face, throat, arms, and legs. For many patients, early symptoms include drooping eyelids or double vision. As the condition progresses, it can affect swallowing, speaking, and breathing.
Most cases of generalized MG are associated with antibodies against the acetylcholine receptor (AChR), though some patients have antibodies targeting MuSK or other proteins at the neuromuscular junction. Treatment is tailored to the antibody profile and severity of symptoms.
How Is Myasthenia Gravis Treated?
The treatment landscape for MG has expanded significantly in recent years. Traditional treatments include acetylcholinesterase inhibitors (like pyridostigmine), corticosteroids, and immunosuppressants. For patients with generalized MG who do not achieve adequate symptom control with conventional therapy, newer options are now available.
Vyvgart (Efgartigimod Alfa)
Efgartigimod alfa, marketed as Vyvgart, is a first-in-class FcRn (neonatal Fc receptor) inhibitor approved by the FDA for adults with generalized MG who are AChR antibody-positive. It works by reducing levels of IgG antibodies, including the harmful autoantibodies responsible for MG symptoms, through a targeted mechanism that does not broadly suppress the immune system.
Vyvgart is given as an IV infusion, once weekly for four weeks, in treatment cycles. Each infusion takes approximately one hour. Patients and their neurologists assess response between cycles to determine whether additional cycles are needed.
Vyvgart Hytrulo is a subcutaneous version of the same medication that can be self-administered by patients at home, offering a flexible option for appropriate candidates.
Imaavy (Nipocalimab)
Imaavy (nipocalimab) is one of the newest FcRn blockers for generalized MG, approved by the FDA in 2025. Like Vyvgart, it works by lowering circulating IgG antibodies, including the autoantibodies that disrupt nerve-to-muscle signaling. What sets Imaavy apart is its broader label: it is approved for adults and for pediatric patients 12 years and older who are antibody-positive for either the acetylcholine receptor (AChR) or muscle-specific kinase (MuSK). That makes it one of the few targeted options available to MuSK antibody-positive patients and to adolescents living with generalized MG.
Imaavy is given as an IV infusion on a steady every-two-weeks schedule rather than in cycles. Treatment begins with a one-time loading dose, and maintenance infusions are short, often around 15 to 30 minutes. For patients who prefer a predictable routine, that consistent schedule can be easier to plan around than cycle-based therapy. Your neurologist will determine whether a cyclic or continuous FcRn approach is the better fit for your symptoms and lifestyle.
Vital Care of Portland dispenses Imaavy for administration at home or in our Happy Valley infusion suite, and our pharmacists coordinate directly with your neurology team on dosing and monitoring.
Site-of-Care Options for MG Patients in Portland
At Vital Care of Portland, we understand that managing a chronic condition like MG means fitting treatment into real life. That is why we offer two convenient site-of-care options for patients receiving infusion therapy:
Home Infusion: Our experienced, CRNI-certified infusion nurse comes to your home so you can receive treatment in a familiar, comfortable environment without the need to travel.
Infusion Suite: Our private infusion suite in Happy Valley is quiet, comfortable, and designed for patients who prefer an in-person clinical setting. We serve the Portland metro area and surrounding communities.
Getting Started with MG Infusion Therapy
If your neurologist has recommended infusion therapy for myasthenia gravis, our intake team will work directly with your physician’s office to coordinate every step of the process, from benefits verification and prior authorization to scheduling and ongoing medication management. We bill through both medical and pharmacy benefits, and we handle the paperwork so you can focus on your care.
To refer a patient or learn more about getting started, contact our intake team:
Fax: 971-484-4950
Phone: 971-484-4940
Visit: vitalcareofportland.com
